动物/体内功能性抗体PD-1
免疫检查点ICK体内Blocking系列之 Invivo anti-mouse PD-1 Recombinant mAb(D265A)
- 最新进展
- 产品信息
- 参考文献
最新进展
动物/体内功能性抗体PD-1
免疫检查点ICK体内Blocking系列之
Invivo anti-mouse PD-1 Recombinant mAb(D265A)
1、产品参数
• 内毒素：<1EU/mg
• Clone：S-5001
• 货号：S0B0594
• 应用类型：In vivo blocking of PD-1/PD-L1 signaling
2、反应机制
This antibody recognizes the same epitope as clone RMP1-14 Programmed death-1(PD-1). PD-1是一种由Pdcd1基因编码的50-55 kDa细胞表面受体，属于CD28家族。它主要在活化T细胞、B细胞及髓系细胞中瞬时表达，可通过结合PD-L1/PD-L2配体传递抑制信号，减弱T细胞活性并促进其凋亡。PD-1对维持免疫耐受至关重要，其缺失会引发自身免疫病变。
3、作用说明
抗体能阻断PD-1与配体的结合，从而恢复T细胞抗肿瘤能力，是具有潜力的癌症免疫治疗候选抗体。
4、推荐用量
常见的使用浓度为10mg/kg (小鼠体重)，成年小鼠的体重大约在20-40克之间，具体可能因品系和个体差异略有不同，所以一般常规推荐用量为200ug/只小鼠。
频率：一周2-3次，建议参考多篇文献，寻找适合自己实验的注射方案。
PD-1 & PD-L1实验结果图：
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| 货号 | 产品名称 | 宿主来源 | 抗原名称 | 克隆号 |
|---|---|---|---|---|
| S0B0038 | Invivo anti-mouse PD-L1 Recombinant mAb | Rat | PD-L1 | 10F.9G2 |
| S0B0101 | Invivo anti-mouse PD-1 Recombinant mAb (RMP1-14) | Rat | PD-1 | RMP1-14 |
| S0B0574 | Invivo anti-mouse CTLA-4 (CD152) mAb | Mouse | CTLA-4 (CD152) | 9D9 |
| S0B0593 | Invivo anti-mouse PD-L1 Recombinant mAb (D265A) | Mouse | PD-L1 | 10F.9G2 |
| S0B0594 | Invivo anti-mouse PD-1 Recombinant mAb (D265A) | Mouse | PD-1 | S-5001 |
| S0B0691 | Invivo anti-mouse CD40L (CD154) Recombinant mAb | Armenian hamster | CD40L | MR-1 |
| S0B0872 | NA/LE Armenian hamster anti-mouse CD40L (CD154) Recombinant mAb | Armenian hamster | CD40L | MR-1 |
| S0B1072 | Invivo anti-human PD-1 (CD279) Recombinant mAb | Mouse | PD-1 (CD279) | S-R545 |
| S0B1073 | Invivo Anti-Mouse CD366 (TIM-3) Recombinant mAb | Rat | CD366 | S-R478-1 |
| S0B1101 | Invivo anti-mouse CTLA-4 (CD152) mAb | Armenian hamster | CTLA-4 (CD152) | S-R534 |
| S0B1361 | Invivo Rat anti-Mouse CD276 Recombinant mAb | Rat | CD276 | S-R633 |
| S0B0555 | Anti-PD-L1 Monoclonal Antibody(Atezolizumab) | Human | PD-L1 | S-SC015 |
| S0B0556 | Anti-PD-L1 Monoclonal Antibody(Avelumab) | Human | PD-L1 | S-SC012 |
| S0B0561 | Anti-PD-L1 Monoclonal Antibody(Durvalumab) | Human | PD-L1 | S-SC0101 |
| S0B0566 | Anti-PD-1 Monoclonal Antibody(Nivolumab) | Human | PD-1 | S-SC016 |
| S0B0567 | Anti-PD-1 Monoclonal Antibody (Pembrolizumab) | Human | PD-1 | — |
| S0B1459 | Invivo anti-mouse PD-1 Recombinant mAb (S-R496) | Rat | PD-1 (CD279) | S-R496 |
产品信息
本文由斯达特技术专家团审核发布
声明：本篇文章在创作中部分采用了人工智能辅助。如有任何内容涉及版权或知识产权问题，敬请告知，我们承诺将在第一时间核实并撤下。
杭州斯达特 (www.starter-bio.com)是优宁维旗下品牌，志在为全球生命科学行业提供优质的抗体、蛋白、试剂盒等产品及研发服务。依托多个开发平台：重组兔单抗、重组鼠单抗、快速鼠单抗、重组蛋白开发平台（E.coli,CHO,HEK293,InsectCells）、一步法ELISA平台，PTM泛修饰抗体平台，已正式通过欧盟98/79/EC认证、ISO9001认证、ISO13485认证。
查看更多产品参考文献
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• A lymph node-targeted cell-nanoadjuvant conjugate enhances dendritic cell-T cell crosstalk for cancer immunotherapy Shuangshuang Hu,Wenzhe,Zhiwen Zhao,Xindi Qian,Linyang Jiang,Ying Cao,Dan Yan,Lesheng Teng,Yaping Li Acta Pharmaceutica Sinica B. 2025 Dec 23 .影响因子：14.6
• A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy Jia-Luo Huang, Lei-Ming Wu, Shu-Qi Wu, Fang-Yu Yuan, Han-Zhuang Weng, Dong Huang, Lu Gan, Shuo-Bin Chen, Gui-Hua Tang & Sheng YinNature Chemical Biolog. 2025 Oct 16 . 影响因子：13.7