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分子别名
Programmed cell death protein 1; Protein PD-1; mPD-1; CD279; Pd1; Pdcd1细胞定位
Cell membraneAccession
Q02242克隆号
S-R496抗体类型
Rat mAb抗体同种型
Rat IgG2a, κ反应种属 ?
Mouse纯化方式
Protein G浓度
5 mg/ml纯度
>95% (Determined by SDS-PAGE)标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
应用
in vivo blocking of PD-1/PD-L signaling稀释度
This antibody recognizes the same epitope as clone 29F.1A12. Programmed cell death protein 1 (PD-1), also known as CD279, is a type I transmembrane protein and a member of the CD28 immunoglobulin superfamily. It is primarily expressed on the surface of various immune cells, including T cells, B cells, macrophages, dendritic cells, and natural killer cells. PD-1 plays a crucial role in regulating immune responses by binding to its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), which are expressed on antigen-presenting cells and tumor cells. When PD-1 interacts with its ligands, it triggers inhibitory signals that downregulate T cell activity, preventing excessive immune responses and promoting self-tolerance. However, this pathway can also be exploited by cancer cells to evade immune surveillance, leading to tumor progression. As a result, PD-1 has become a key target in cancer immunotherapy, with several anti-PD-1 antibodies approved for treating various cancers, achieving significant and durable efficacy in some patients.
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