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宿主来源
Armenian hamster抗原名称
CD40L分子别名
CD40 ligand, CD40-L, T-cell antigen Gp39, TNF-related activation protein (TRAP), Tumor necrosis factor ligand superfamily member 5, CD154, Cd40lg, Cd40l, Tnfsf5Accession
P27548克隆号
MR-1抗体类型
Armenian hamster mAb反应种属 ?
Ms纯化方式
Protein G浓度
5 mg/ml纯度
>95% (Determined by SDS-PAGE)内毒素含量
<2EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS, pH 7.4, Contains no stabilizers or preservatives
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
应用
in vitro blocking of CD40/CD40L signaling ,in vivo blocking of CD40/CD40L signaling ,ELISA
CD40L, also known as gp39, tumor necrosis factor-related activation protein (TRAP), or T cell-B cell activating molecule (T-BAM), is a 33-kDa type II transmembrane glycoprotein consisting of 266 amino acids. It has a 214-amino acid extracellular domain that shares a high degree of homology with tumor necrosis factor (TNF) at the amino acid level. The primary function of CD40L is to participate in immune responses by binding to CD40, a molecule widely expressed on immune cells. The CD40-CD40L interaction activates various signaling pathways, regulating a broad range of cellular responses, including proliferation, differentiation, and cell death. Additionally, CD40L expression is typically inducible and primarily found on activated CD4+ T lymphocytes, with partial expression on activated CD8+ T cells, basophils, mast cells, and NK cells.
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