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Invivo anti-human PD-1 (CD279) Recombinant mAb

Programmed cell death protein 1,Protein PD-1,hPD-1,PDCD1

货号： S0B1072

Datasheet COA
  • 价格： ￥1,788
  • 规格：
  • 数量：
斯达特大包装询价 大包装询价

产品介绍 评论(0)

产品规格

  • 宿主来源

    Mouse

  • 抗原名称

    PD-1 (CD279)

  • 分子别名

    Programmed cell death protein 1; Protein PD-1; hPD-1; PDCD1

  • 细胞定位

    Cell membrane

  • Accession

    Q15116

  • 克隆号

    S-R545

  • 抗体类型

    Mouse mAb

  • 抗体同种型

    IgG1,k

  • 应用

    in vitro PD-1 neutralization, in vivo PD-1 blockade in humanized mice, WB

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein G

  • 浓度

    5 mg/ml

  • 内毒素含量

    <2EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;

    -20 °C for 3 months under sterile conditions; 

    -80 °C for 24 months under sterile conditions.

    Please avoid repeated freeze-thaw cycles.

稀释度
应用 稀释度 推荐种属
WB 1:1000 Hu
背景介绍

  • Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).

  • 免疫印迹

    • WB result of Invivo anti-human PD-1 (CD279) Recombinant mAb
      Primary antibody: Invivo anti-human PD-1 (CD279) Recombinant mAb at 1/1000 dilution
      Lane 1: PD-1 His Tag Protein, Human 1 µg
      Secondary antibody: Goat Anti-mouse IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 32 kDa
      Observed MW: 23~40 kDa

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