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Invivo anti-mouse PD-1 Recombinant mAb (D265A)

Programmed cell death protein 1,mPD-1,CD279

货号： S0B0594

Datasheet COA
  • 价格： ￥2,700
  • 规格：
  • 数量：
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  • Invivo mouse IgG1 isotype control (D265A)

    规格：1mg

    价格：￥700

    • 产品介绍 引用文献(2) 评论(0)

    产品规格

    • 宿主来源

      Mouse

    • 抗原名称

      PD-1

    • 分子别名

      Programmed cell death protein 1, mPD-1, CD279

    • 细胞定位

      Cell membrane

    • Accession

      Q02242

    • 克隆号

      S-5001

    • 抗体类型

      Recombinant mAb

    • 抗体同种型

      Mouse IgG1 D265A, κ

    • 同型对照

      Invivo mouse IgG1 isotype control (D265A)

    • 突变

      D265A

    • 应用

      In vivo blocking of PD-1/PD-L signaling

    • 反应种属 ?

      Ms

    • 纯化方式

      Protein G

    • 浓度

      Lot specific* (generally 5 to 20 mg/ml)*

    • 内毒素含量

      <1EU/mg

    • 标记

      Unconjugated

    • 性状

      Liquid

    • 缓冲体系

      PBS pH7.4, containing no preservative

    • 储存条件

      2 to 8 °C for 2 weeks under sterile conditions;

      -20 °C for 3 months under sterile conditions;

      -80 °C for 24 months under sterile conditions.

      Please avoid repeated freeze-thaw cycles.

    • 稀释度

    背景介绍

    • This antibody recognizes the same epitope as clone RMP1-14.

      Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).

    • 验证数据

      • Anti-tumor efficacy of S0B0594 in B16-OVA tumor-bearing mice

      • Anti-tumor efficacy of S0B0594 in MC38 Xenograft Model

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