Fc γ RIIIa/CD16a(F176 Protein, S197P) His Tag Protein, Human
Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A,CD16a Antigen,Fc-Gamma RIII-Alpha,Fc-Gamma RIII,Fc-gamma RIIIa,FcRIII,FcRIIIa,FcR-10,IgG Fc Receptor III-2,CD16a,FCGR3A,CD16A,FCG3,FCGR3,IGFR3
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Fc γ RIIIa/CD16a(V176) His Tag Protein, Human
规格：50μg
价格：￥1,800.00
Fc γ RIIIa/CD16a(F176) His Tag Protein, Human
规格：50μg
价格：￥1,800.00
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物种
Human分子别名
Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A, CD16a Antigen, Fc-Gamma RIII-Alpha, Fc-Gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc Receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3Accession
P08637-1表达序列
Gly17-Gln208, with C-terminal His表达宿主
HEK293分子量
35-45 kDa(Reducing)纯度
＞95%, by SDS-PAGE under reducing conditions内毒素含量
<0.1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs can be divided into three types: RI (CD64), RII (CD32) and RIII (CD16). CD16 is a low-affinity Fc receptor, which has been identified as Fc γ RIII (a (CD16a) and Fc γ RIIIb (CD16b), respectively. These receptors bind to the Fc portion of the IgG antibody and are encoded by two different highly homologous genes in a cell type-specific manner. In humans, CD16a is a 50-70 kDa type I transmembrane activated receptor expressed in NK cells, T cells, monocytes and macrophages, involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity and clearance of immune complexes. Abnormal expression or mutation of CD16a is associated with susceptibility to viral infection, systemic lupus erythematosus and neutropenia in alloimmune newborns. In humans, mutations in a single amino acid of CD16a may affect susceptibility to autoimmune diseases or response to therapeutic IgG antibodies.
生物活性
- Anti-His antibody Immobilized on CM5 Chip captured CD16a(F176, S197P) His Tag, Human (Cat. No. UA020010), can bind IgG1-Fc (UA050001) with an affinity constant of 0.94 μM as determined in SPR assay (Biacore T200).
电泳
- Fc γ RIIIa/CD16a(F176, S197P) His Tag, Human，1μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.
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