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物种
Human分子别名
A1A, A1AT, AAT, alpha-1-antitrypsin, alpha1AT, nNIF, PI, PI1, SERPINA1Accession
NP_000286.3表达序列
Glu25-Lys418 with His Tag at C-Terminus
表达宿主
HEK293分子量
53-68kDa (Reducing)纯度
＞95% by SDS-PAGE标记
Unconjugated标签
His Tag性状
Lyophilized powder缓冲体系
PBS, PH7.4, 5% trehalose溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
Hunt JM, Tuder R. Alpha 1 anti-trypsin: one protein, many functions. Curr Mol Med. 2012 Aug;12(7):827-35.
Shabat Y, Ya'acov AB, Ilan Y. Alpha-1 Anti-trypsin Exerts a Hepatoprotective Effect on Immune-mediated Hepatitis and Acetaminophen-induced Liver Injury. J Clin Transl Hepatol. 2018 Dec 28;6(4):345-349.
SerpinA1, also known as Alpha-1 Antitrypsin (AAT), is a prototype member of the Serpin superfamily, which are serine protease inhibitors. This inhibitor specifically targets the protease neutrophil elastase. Primarily produced in the liver, Alpha-1 Antitrypsin functions as an antiprotease, with its main role being the inactivation of neutrophil elastase to prevent tissue damage. SerpinA1 (Alpha-1 Antitrypsin), an acute phase protein and a classical inhibitor of neutrophil elastase, is localized within lipid rafts in primary human monocytes in vitro. Its association with monocytes is modulated by cholesterol levels; it is inhibited by cholesterol-depleting agents such as nystatin, filipin, methyl-beta-cyclodextrin (MbetaCD), and oxidized low-density lipoprotein (oxLDL), and conversely, enhanced by the presence of free cholesterol.
电泳(SDS-PAGE)
2μg (R: reducing condition, N: non-reducing condition).
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