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物种
Human分子别名
LILRB5,CD85c,LIR-8Accession
O75023-1表达序列
Gly24-Gly458, with C-terminal His&Avi表达宿主
HEK293分子量
72-80kDa (Reducing)
纯度
>95% by SDS-PAGE内毒素含量
<1EU/μg标记
Biotin标签
Avi Tag, His Tag性状
Lyophilized powder缓冲体系
PBS, pH7.4, 5% trehalose溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
TEDLA N, LEE CW, BORGES L, et al. Differential expression of leukocyte immunoglobulin-like receptors on cord blood-derived human mast cell progenitors and mature mast cells.[J]. Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society,2008,83(2):334-343.
LILRB5, also known as CD85c and LIR-8, consists of an extracellular domain (ECD) with four Ig-like domains, a transmembrane segment, and a cytoplasmic domain with two immunoreceptor tyrosine-based inhibitory motifs (ITIM). LILRB5 is expressed in mast cell granules and the release of soluble LILRB5 following IgE FcR-dependent stimulation, which has potential for amplification of mast cell-dependent, inflammatory responses. The mRNA expression of all LILRB family members was significantly associated with the infiltration of B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells in liver cancer.
电泳
1μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
The purity of Biotinylated LILRB5/CD85c/LIR8 His&Avi Tag Protein, Human is greater than 90% as determined by SEC-HPLC.
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