Biotinylated Fc γ RIIIb/CD16b(NA2) His&Avi Tag Protein, Human

Receptors for the Fc region of IgG (Fc gamma R) are members of the Ig superfamily. Based on their genetic organization and molecular structure, three classes of human Fc γ Rs can be identified: RI (CD64), RII (CD32), and RIII (CD16), which produce a variety of isoforms. Fc γ RI is a high-affinity receptor that binds monomeric IgG. Both Fc γ RII and RIII are low-affinity receptors that bind IgG as immune complexes. Two genes have been identified for human Fc γ RIII, A and B, which encode a transmembrane receptor and a glycosylphosphatidylinositol (GPI) anchored protein, respectively. Three allelic variants of Fc γ RIIIB, NA-1, NA-2, and SH were present. CD16 inhibits a variety of cellular functions such as B cell activation/proliferation and mast cell degranulation, cannot mediate antibody-dependent cytotoxicity and phagocytosis, acts as a trap for peripheral circulating immune complexes, and binds IgG complexes but does not activate neutrophils. CD16 regulates the inflammatory process by interacting with CR3 and CR4 and inducing IL-6 and IL-8 production by monocytes.