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产品中心 药物靶点和Fc受体 药物靶点

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MSLN/Mesothelin (296-580) His Tag Protein, Human

MPF

价格 ￥3,000.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010166
规格
数量
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产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    MPF

  • Accession

    Q13421-1

  • 表达序列

    Glu296-Gly580, with C-8*His

  • 表达宿主

    HEK293

  • 分子量

    36-50kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 稀释度

背景介绍

  • Mesothelin (MSLN) is a cell surface-bound, glycosylphosphatidylinositol (GPI) anchored protein, whose normal expression is restricted to the mesothelial cells of the pleura, pericardium, peritoneum, and tunica vaginalis in men, whereas very low MSLN expression (trace amounts) has also been observed in the epithelial lining of the ovaries, fallopian tubes, and rete testis. Mesothelin (MSLN) is a tumor differentiation antigen normally restricted to the body’s mesothelial surfaces, but significantly overexpressed in a broad range of solid tumors. For this reason, MSLN has emerged as an important target for the development of novel immunotherapies.

  • 电泳

    • 2μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized MSLN/Mesothelin (296-580) His Tag, Human (Cat. No. UA010166) at 2.0μg/mL (100μL/well) can bind Anti-Human MSLN Monoclonal Antibody (Amatuximab) with EC50 of 1.56-1.89ng/mL.

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