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物种
Human分子别名
Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNAP, TNSALP, Alkaline phosphatase 2, Alkaline phosphatase liver/bone/kidney isozyme, Phosphoamidase, Phosphocreatine phosphatase, Akp-2, Akp2Accession
P09242表达序列
TPhe18-Ser502, with C-His Tag
表达宿主
HEK293分子量
Predicted MW: 55.3 kDa Observed MW: 65-90 kDa
纯度
>95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
Alkaline Phosphatase, Tissue-Nonspecific Isozyme (TNAP) is a ubiquitously expressed enzyme encoded by the ALPL gene. As the predominant alkaline phosphatase in humans, it is crucial for bone and tooth mineralization. TNAP hydrolyzes inorganic pyrophosphate, a potent mineralization inhibitor, and provides inorganic phosphate to promote hydroxyapatite crystal growth. Beyond its skeletal role, TNAP is also vital in neuronal development, vitamin B6 metabolism, and modulating intestinal inflammation. Mutations in ALPL cause hypophosphatasia, a metabolic bone disorder characterized by defective mineralization. Thus, TNAP serves as a central regulator of phosphate metabolism across multiple physiological systems.
电泳
2μg（R: reducing conditions）
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