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产品规格
物种
Human分子别名
Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8)Accession
Q16552表达序列
Gly24-Ala155, with C-10*His
表达宿主
HEK293分子量
Theoretical:16.8kDa Actual:17, 20kDa纯度
>95% by SDS-PAGE内毒素含量
<1EU/μg活性
Immobilized Recombinant Human IL-17RA (C-Fc) at 4 μg/mL (50 μL/well) can bind Human IL-17A, His tag with EC50 of 5.019-5.731 ng/ml.标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
0.2M PBS, 1mM EDTA, pH7.4.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
背景介绍
IL-17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
电泳
2μg（R: reducing conditions）
ELISA
Immobilized Recombinant Human IL-17RA (C-Fc) at 4 μg/mL (50 μL/well) can bind Human IL-17A, His tag with EC50 of 5.019-5.731 ng/ml.
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