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产品中心 蛋白 细胞因子

BDNF Protein, Human/Mouse/Rat

Neurotrophic factor BDNF precursor form,proBDNF,Alternative names,Abrineurin,Brain-derived neurotrophic factor

价格 ￥1,350.00 （ 供应商现货 ： 3-5个工作日）
货号 UA100029
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human, Mouse, Rat

  • 分子别名

    Neurotrophic factor BDNF precursor form,proBDNF, Alternative names,Abrineurin,Brain-derived neurotrophic factor

  • Accession

    P23560

  • 表达序列

    His129-Arg247

  • 表达宿主

    E.coli

  • 分子量

    13 KDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.01EU/μg

  • 活性

    Immobilized Human TrkB (C-6His) at 5 μg/mL (100 μL/well) can bind Human/Murine/Rat BDNF: Biotinylated by NHS-biotin prior to testing. The EC50 of Human/Murine/Rat BDNF is ≤20 ng/mL.

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM PB, 400mM NaCl, pH 7.2.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件


    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

背景介绍

  • Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease.

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