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物种
Mouse分子别名
Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17Accession
Q62386表达序列
Thr22-Ala158 , with 6His tag at the C-terminus
表达宿主
HEK293分子量
17-26 KDa, reducing conditions纯度
>95% by SDS-PAGE内毒素含量
<0.01EU/μg活性
Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells.The EC50 for this effect is 0.25-1.25 ng/ml.标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH 7.4.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
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