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产品中心 蛋白 细胞因子

HB-EGF Protein, Human

Proheparin-binding EGF-like growth factor (HB-EGF),Heparin-binding EGF-like Growth Factor,DT-R

价格 ￥480.00 （ 1-2周）
货号 UA100024
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Proheparin-binding EGF-like growth factor (HB-EGF),Heparin-binding EGF-like Growth Factor,DT-R

  • Accession

    Q99075

  • 表达序列

    Asp63-Leu148

  • 表达宿主

    E.coli

  • 分子量

    Approximately 9.7 kDa, a single non-glycosylated polypeptide chain containing 86 amino acids.

  • 纯度

    ＞97% by SDS-PAGE or HPLC.

  • 活性

    Fully biologically active when compared to standard. The ED₅₀ as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1 ng/ml, corresponding to a specific activity of ≥ 1.0×10⁶ U/mg.

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    10 mM PB, with 500 mM NaCl, 5% (v/v) Trehalose, pH 7.4.

  • 溶解方法

    Before use this product, please read the direction below carefully.
    This vial must be briefly centrifuged prior to opening to bring the contents to the bottom.
    Reconstitute in a sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml.
    Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃.
    Further dilutions should be made in appropriate buffered solutions.

  • 储存条件

    For long term storage, the product should be stored ≤ -20℃.
    Please avoid repeated freeze-thaw cycles after reconstitution.
    12 months from date of receipt, -20 to -70℃ as supplied.
    1 month, 2 to 8℃ under sterile conditions after reconstitution.
    3 months, -20 to -70℃ under sterile conditions after reconstitution.

背景介绍

  • Heparin-binding epidermal growth factor (HB-EGF) -like growth factor (EGF) is found in cerebral neurons. Its expression is increased after hypoxic or ischemic injury, which also stimulates neurogenesis. HB-EGF has been implicated as a participant in a variety of normal physiological processes such as blastocyst implantation, wound healing, and in pathological processes such as tumor growth, SMC hyperplasia and atherosclerosis. HB-EGF is an 87 amino acid mitogenic and chemotactic glycoprotein containing an EGF-like domain with six conserved cysteine residues. Human HB-EGF shares about 73% and 76% a.a. sequence identity with murine and rat HB-EGF. Recombinant human HB-EGF is a 9.7kDa protein containing 86 amino acid residues.

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