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产品中心 蛋白 细胞因子

Leptin Protein, Human

LEPD,Obesity protein (OB),LEP

价格 ￥800.00 （ 1-2周）
货号 UA100022
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    LEPD, Obesity protein (OB), LEP

  • Accession

    P41159

  • 表达序列

    Val22-Cys167

  • 表达宿主

    E.coli

  • 分子量

    Approximately 16.0 kDa, a single non-glycosylated polypeptide chain containing 146 amino acids.

  • 纯度

    ＞97% by SDS-PAGE or HPLC.

  • 活性

    Fully biologically active when compared to standard. The ED₅₀ as determined by a chemotaxis bioassay using human Leptin R transfected BaF3 murine proB cells is less than 2 ng/ml, corresponding to a specific activity of ≥ 5.0×10⁵ IU/mg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    50 mM PB, with 0.02% (v/v) Tween-20, pH 3.5.

  • 溶解方法

    Before use this product, please read the direction below carefully.
    This vial must be briefly centrifuged prior to opening to bring the contents to the bottom.
    Reconstitute in a sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml.
    Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃.
    Further dilutions should be made in appropriate buffered solutions.

  • 储存条件

    For long term storage, the product should be stored ≤ -20℃.
    Please avoid repeated freeze-thaw cycles after reconstitution.
    12 months from date of receipt, -20 to -70℃ as supplied.
    1 month, 2 to 8℃ under sterile conditions after reconstitution.
    3 months, -20 to -70℃ under sterile conditions after reconstitution.

背景介绍

  • Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. The absence of leptin (or its receptor) leads to uncontrolled food intake and resulting obesity. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Human Leptin is a 16.0kDa protein containing 146 amino acid residues.

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