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物种
Human分子别名
GNovel Neurtrophin-1/B-Cell Stimulating Factor-3Accession
Q9UBD9表达序列
Leu28-Phe225
表达宿主
E.coli分子量
Approximately 22.3 kDa, a single non-glycosylated polypeptide chain containing 198 amino acids.纯度
＞96% by SDS-PAGE or HPLC.活性
Fully biologically active when compared to standard. The ED₅₀ as determined by a cell proliferation assay using human TF-1 cells is less than 4 ng/ml, corresponding to a specific activity of ≥ 2.5×10⁵ IU/mg in the presence of human CNTF R alpha标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
30% Acetonitrile and 0.1% TFA.
溶解方法
Before use this product, please read the direction below carefully.
This vial must be briefly centrifuged prior to opening to bring the contents to the bottom.
Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃.
Further dilutions should be made in appropriate buffered solutions.储存条件
For long term storage, the product should be stored ≤ -20℃.
Please avoid repeated freeze-thaw cycles after reconstitution.
12 months from date of receipt, -20 to -70℃ as supplied.
1 month, 2 to 8℃ under sterile conditions after reconstitution.
3 months, -20 to -70℃ under sterile conditions after reconstitution.
Novel Neurotrophin-1 (NNT-1) or B-Cell Stimulating Factor-3 (BSF-3) , is a new member of the IL-6 family of structurally related cytokines that includes IL-6, CNTF, LIF, CT-1, IL-11 and OSM. All family members share the receptor subunit gp130 that belong to the type I cytokine receptor superfamily. Ligand binding leads to gp130 homodimerization or heterodimerization (with LIF receptor or OSM receptor beta) , and induces cell signaling and functional activity. For several family members, including CNTF, IL-6, and IL-11, binding of the ligand to a specific receptor alpha subunit (CNTF R alpha, IL-6 R alpha, or IL-11 R alpha) is required prior to gp130 homo- or hetero-dimerization. Recombinant human NNT-1/BCSF-3 a 22.3kDa protein containing 198 amino-acid residues.
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