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产品中心 药物靶点和Fc受体 小分子药物靶点蛋白

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ACSS1 His Tag Protein, Human

ACSS1,ACAS2L,KIAA1846,Acetate--CoA ligase 2

价格 ￥1,180.00 （ 供应商现货 ： 3-5个工作日）
货号 UA085075
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    ACSS1, ACAS2L, KIAA1846, Acetate--CoA ligase 2

  • Accession

    Q9NUB1

  • 表达序列

    Ala38-Lys689 with His Tag at the N-Terminus

  • 表达宿主

    E.coli

  • 分子量

    70-100kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & HPLC

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Liquid

  • 缓冲体系

    50mM Tris, 150mM NaCl, pH7.5, 1mM DTT, 10%Glycerol

  • 储存条件

    Stable for 12 months upon stored at -80℃ from the date of receipt. And avoid repeated freeze-thaws cycles.

  • 文献引用

    1. Fu, X., et al. (2025). ACSS1 co-opts acetyl-CoA metabolism to drive DNA repair and undermine radiotherapy efficacy in breast cancer. Cell Death & Disease, 17, 119.
    2. Schug, Z.T., et al. (2015). Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), 57-71.
    3. Fujino, T., et al. (2001). Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. Journal of Biological Chemistry, 276(14), 11420-11426.

背景介绍

  • ACSS1 (Acyl-CoA Synthetase Short-Chain Family Member 1) is a key metabolic enzyme localized in the mitochondrial matrix. Encoded by the human ACSS1 gene on chromosome 20p11.21, the protein is 689 amino acids long and features an N-terminal acetyl-CoA synthetase domain and two AMP-binding domains.

    Functionally, ACSS1 catalyzes the ATP-dependent conversion of acetate and CoA into acetyl-CoA, a critical step in mitochondrial energy metabolism that supplies the TCA cycle. Under glucose deprivation, ACSS1 utilizes alternative carbon sources like acetate to sustain energy production in high-energy organs such as the heart and brain. Its enzymatic activity is regulated by SIRT3-mediated deacetylation at a key lysine residue (K642 in humans).

    Dysregulation of ACSS1 expression and function is implicated in various diseases. In oncology, ACSS1 is aberrantly overexpressed in breast cancer, AML, and melanoma, where it rewires acetyl-CoA metabolism to drive DNA repair, promote tumor growth and metastasis, and is associated with poor prognosis and therapy resistance. Furthermore, reduced ACSS1 function may contribute to energy failure in neurodegenerative diseases and is linked to metabolic disorders including nonalcoholic fatty liver disease and sarcopenia.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of ACSS1 His Tag Protein, Human is more than 95% determined by SEC-HPLC.

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