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物种
Human分子别名
Long-chain acyl-CoA synthetase 6, LACS 6, ACS2, FACL6Accession
Q9UKU0表达序列
His46-Met697 with GST Tag at the N-Terminus
表达宿主
E.coli分子量
100-130kDa (Reducing)纯度
＞90% by SDS-PAGE标记
Unconjugated标签
GST Tag性状
Liquid缓冲体系
50mM Tris, 150mM NaCl, pH7.5, 1mM DTT, 10%Glycerol
储存条件
Stable for 12 months upon stored at -80℃ from the date of receipt. And avoid repeated freeze-thaws cycles.
文献引用
1. Kurotaki, A., et al. (2021). Substrate Specificity of Human Long-Chain Acyl-CoA Synthetase ACSL6 Variants. Biological & Pharmaceutical Bulletin, 44(10), 1571-1575.
2. Fernandez, R.F., et al. (2024). ACSL6 is required for brain docosahexaenoic acid retention and neuroprotection during aging. JCI Insight, 9(10), e178147.
3. Zhang, S., et al. (2026). Roles of ACSL6 in lipid homeostasis and stress responses in the nervous system. Metabolic Brain Disease, 41(1), 1-12.
ACSL6 is encoded by the ACSL6 gene located on human chromosome 5q31. The full-length protein comprises approximately 697 amino acids with a molecular weight of about 77.8 kDa. The gene produces multiple splice variants, with two major variants, ACSL6V1 and ACSL6V2, sharing a conserved fatty acid Gate domain but encoding slightly different short motifs that differ in aromatic amino acid residues. ACSL6 is highly and specifically expressed in the brain, erythrocytes, and testis, with a critical role in neurons, particularly in maintaining DHA levels.
Core Functions: The core function of ACSL6 is to activate long-chain polyunsaturated fatty acids, particularly DHA, and traffic them into membrane phospholipids, which is crucial for maintaining neuronal membrane lipid composition and synaptic plasticity. Experimental validation has shown that the ACSL6V2 variant possesses extremely high affinity for DHA and is the primary enzyme responsible for maintaining DHA homeostasis in the brain.
电泳
2μg (R: reducing condition, N: non-reducing condition).
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