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产品中心 药物靶点和Fc受体 小分子药物靶点蛋白

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CBLB/RNF56(36-426) Protein, Human

CBL-B,CBLB,RNF56,Casitas B-lineage lymphoma proto-oncogene b,RING finger protein 56

价格 ￥2,800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA085043
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    CBL-B, CBLB, RNF56, Casitas B-lineage lymphoma proto-oncogene b, RING finger protein 56

  • Accession

    Q13191

  • 表达序列

    Pro36-Phe426

  • 表达宿主

    E.coli

  • 分子量

    40-55kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & HPLC

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Liquid

  • 缓冲体系

    50mM Tris, 200mM NaCl, 1mM DTT, pH7.5, 10%Glycerol

  • 储存条件

    Stable for 12 months upon stored at -80℃ from the date of receipt. And avoid repeated freeze-thaws cycles.

  • 文献引用

    1. PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Science Signaling, 2(76), ra30.
    2. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature, 403(6766), 211-216.
    3. Cbl-b regulates the CD28 dependence of T-cell activation. Nature, 403(6766), 216-220.

背景介绍

  • CBLB (Casitas B-lineage Lymphoma Proto-Oncogene B), also known as RNF56 (RING Finger Protein 56), is an E3 ubiquitin-protein ligase that plays a critical role as a negative regulator of immune receptor signaling. It belongs to the CBL family of RING finger E3 ubiquitin ligases and is encoded by the gene located on chromosome 3q13.11.

    Mechanism of Action: CBLB promotes proteasome-mediated protein degradation by transferring ubiquitin from specific E2 ubiquitin-conjugating enzymes to substrate proteins. Structurally, it contains several functional domains: an N-terminal tyrosine kinase-binding (TKB) domain (composed of a four-helix bundle, a Ca²⁺-binding EF-hand, and a variant SH2 domain), a proline-rich domain, a nuclear localization signal, a C3HC4-type RING-HC finger, and a ubiquitin-associated (UBA) domain. The RING finger domain confers the E3 ligase activity essential for ubiquitination.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of CBLB/RNF56(36-426) Protein, Human is more than 95% determined by SEC-HPLC.

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