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物种
Human分子别名
ACSL5, ACS5, FACL5Accession
Q9ULC5表达序列
Met1-Asp683 with GST Tag at the N-Terminus
表达宿主
HEK293分子量
70-100kDa (Reducing)
纯度
＞90% by SDS-PAGE标记
Unconjugated标签
GST Tag性状
Liquid缓冲体系
50mM Tris, 150mM NaCl, pH7.5, 1mM DTT, 10%Glycerol
储存条件
Stable for 12 months upon stored at -80℃ from the date of receipt. And avoid repeated freeze-thaws cycles.
文献引用
1. Wang, Y., et al. (2021). ACSL5 is a Biomarker for Ferroptosis and a Potential Therapeutic Target in Gastric Cancer. Frontiers in Oncology, 11, 675944.
2. Kuwata, H., & Hara, S. (2019). Role of acyl-CoA synthetase ACSL5 in the metabolism of arachidonic acid to prostaglandins. Biochemical and Biophysical Research Communications, 517(4), 524-528.
3. Doll, S., et al. (2017). ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nature Chemical Biology, 13(1), 91-98.
ACSL5 (Acyl-CoA Synthetase Long-Chain Family Member 5) is a key enzyme located in the outer mitochondrial membrane and endoplasmic reticulum. It belongs to the acyl-CoA synthetase family, which catalyzes the essential activation step of long-chain fatty acids (typically C16-C20) by converting them into their corresponding acyl-CoA esters. This reaction, dependent on ATP and Coenzyme A, is the first and committed step in fatty acid metabolism, preparing fatty acids for subsequent processes such as β-oxidation (for energy production), phospholipid synthesis (for membrane biogenesis), or triglyceride storage.
ACSL5 expression and activity are implicated in several diseases. Its dysregulation is associated with metabolic disorders (e.g., insulin resistance, non-alcoholic fatty liver disease), where altered lipid partitioning plays a key role. In cancer, ACSL5 exhibits context-dependent roles, acting as a tumor suppressor in colorectal and gastric cancers, possibly by modulating cell death pathways, while potentially supporting tumor growth in other contexts by fueling lipid anabolism. This dual nature makes it a complex but interesting target for metabolic and cancer research.
电泳
2μg (R: reducing condition, N: non-reducing condition).
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