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产品中心 药物靶点和Fc受体 小分子药物靶点蛋白

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GPX4 Flag&His tag Protein, Human

GluA4,GLUR4,GLUR4C,GLURD,GPx-4,GSHPx-4,MCSP,NEDSGA,PHGPx

价格 ￥1,100.00 （ 供应商现货 ： 3-5个工作日）
货号 UA085007
规格
数量
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产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    GluA4,GLUR4,GLUR4C,GLURD,GPx-4,GSHPx-4,MCSP,NEDSGA,PHGPx

  • Accession

    P36969-1

  • 表达序列

    Gly26-Phe197 with Flag Tag at the N-Terminus, and His Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    20-25kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & > 85% SEC-HPLC

  • 标记

    Unconjugated

  • 标签

    Flag Tag, His Tag

  • 性状

    Lyophilized powder

  • 缓冲体系

    20mM Tris, 150mM NaCl, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Sutherland M, Shankaranarayanan P, Schewe T, Nigam S. Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism. Biochem J. 2001 Jan 1;353(Pt 1):91-100.
    2.Schwarz M, Löser A, Cheng Q, Wichmann-Costaganna M, Schädel P, Werz O, Arnér ES, Kipp AP. Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides. Redox Biol. 2023 Feb;59:102593.

背景介绍

  • GPX4 (Glutathione Peroxidase 4) is a pivotal antioxidant enzyme, unique for its active site containing the rare amino acid selenocysteine, which is essential for its function. It directly reduces a broad spectrum of phospholipid hydroperoxides within cell membranes, thereby maintaining membrane integrity and playing a central role in inhibiting ferroptosis—a form of iron-dependent, non-apoptotic cell death. Its functions are critical for sperm development, T-cell immunity, and neuronal survival. Clinically, GPX4 is a key therapeutic target, as its dysfunction is implicated in conditions ranging from male infertility and neurodegenerative diseases to epilepsy and cancer, with modulating its activity being a promising strategy for treating ferroptosis-related pathologies.

  • 电泳

    • 2μg (R: reducing condition, N:non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of GPX4 Flag&His tag Protein，Human is more than 85% determined by SEC-HPLC.

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