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产品中心 药物靶点和Fc受体 小分子药物靶点蛋白

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STAT6 His&Strep Tag Protein, Human

STAT6C,STAT6B,interleukin-4 induced,IL-4-STAT,D12S1644

价格 ￥1,450.00 （ 供应商现货 ： 3-5个工作日）
货号 UA085004
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    STAT6C,STAT6B, interleukin-4 induced,IL-4-STAT,D12S1644

  • Accession

    P42226-1

  • 表达序列

    Met1-Trp847 with His&Strep Tag at the C-Terminus

  • 表达宿主

    Baculovirus-InsectCells

  • 分子量

    95-110kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & > 90% SEC-HPLC

  • 标记

    Unconjugated

  • 标签

    Strep Tag, His Tag

  • 性状

    Liquid

  • 缓冲体系

    50mM Hepes,200mM NaCl,20%Glycerol,1mM DDT

  • 储存条件

    Stable for 12 months upon stored at -80℃ from the date of receipt.

    And avoid repeated freeze-thaws cycles.

  • 文献引用

    1.Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M. STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology. Pathol Res Pract. 2021 Jul;223:153477.
    2.Chao H, Zheng L, Hsu P, He J, Wu R, Xu S, Zeng R, Zhou Y, Ma H, Liu H, Tang Q. IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation. JCI Insight. 2023 Mar 22;8(6):e157091.

背景介绍

  • STAT6 (Signal Transducer and Activator of Transcription 6) is a transcription factor that plays a pivotal role in the cellular response to interleukin-4 (IL-4). It is activated through IL-4-induced tyrosine phosphorylation. Its primary function is to mediate most of IL-4's effects, including promoting cell survival by inducing the expression of the anti-apoptotic gene BCL2L1/BCL-X(L). To activate transcription, STAT6 requires interaction with coactivator proteins like p300 and CBP. A key physiological characteristic is its direct interaction with NF-κB, which underlies the synergistic transcriptional activation observed between the IL-4 and NF-κB signaling pathways. Clinically, its central role in IL-4-mediated responses makes it a molecule of interest in immune-related processes.

  • 电泳

    • 2μg (R: reducing condition, N:non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of STAT6 His&Strep Tag Protein, Human is more than 90% determined by SEC-HPLC.

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