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产品中心 药物靶点和Fc受体 小分子药物靶点蛋白

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SKP1 His Tag Protein, Human

EMC19,OCP2,SKP1A,TCEB1L

价格 ￥3,480.00 （ 供应商现货 ： 3-5个工作日）
货号 UA085001
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    EMC19,OCP2,SKP1A,TCEB1L

  • Accession

    P63208

  • 表达序列

    Met1-Lys163 with His Tag at the N-Terminus

  • 表达宿主

    E.coli

  • 分子量

    21kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Schulman BA, Carrano AC, Jeffrey PD, et al. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature. 2000;408(6810):381-386.

背景介绍

  • SKP1 (S-phase kinase-associated protein 1) is a core adaptor subunit of the SCF (SKP1-Cullin1-F-box) class of E3 ubiquitin ligases. By bridging the Cullin-1 scaffold to variable F-box proteins, SKP1 determines which substrates are poly-ubiquitylated and subsequently degraded by the 26 S proteasome. In this way SKP1 controls eukaryotic cell-cycle transitions, signal transduction, transcription, circadian rhythms and stress responses.

  • 电泳

    • 2μg (R: reducing condition).

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