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产品中心 药物靶点和Fc受体 小分子药物靶点蛋白

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USP7 Flag&His Tag Protein, Human

UBP7,HAUSP,USP7

价格 ￥1,050.00 （ 1-2周）
货号 UA070051
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    UBP7,HAUSP,USP7

  • 表达序列

    Asn2-Asn1102

  • 表达宿主

    Baculovirus-InsectCells

  • 分子量

    131kDa (Reducing)

  • 纯度

    ＞90% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Flag Tag, His Tag

  • 性状

    Liquid

  • 缓冲体系

    20mMTris,500mM Nacl,10%Glycerol,3mM DTT,pH8.0.

  • 储存条件

    ·12 months from date of receipt, -20 to -70 °C as supplied.
    ·1 month, 2 to 8 °C under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Zakut-Houri R., et al.,(1985), Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4:1251-1255.
    Lamb P., et al., (1986), Characterization of the human p53 gene.Mol. Cell. Biol. 6:1379-1385.
    Harlow E., et al.,(1985), Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.Mol. Cell. Biol. 5:1601-1610.

背景介绍

  • USP7 is a widely expressed protein that belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase core, N- and C-terminal domains required for protein-protein interactions. USP7 contributes to epigenetic silencing of homeotic genes by Polycomb (Pc). USP7 cleaves ubiquitin fusion protein substrates. It deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2. USP7 also induces TP53-dependent cell growth repression and apoptosis.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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