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物种
Human分子别名
CLD1, ILVASC, SEMP1Accession
O95832浓度
1mg/ml by Nanodrop表达序列
Claudin 1 (full ength) with His-TGP-Flag tag at the C-terminus
分子量
55.5kDa
纯度
＞90% by SDS-PAGE内毒素含量
<0.1EU/μg活性
Immobilized Claudin-1 Flag-His tag Protein, Human (Detergent) (Cat. No. UA060017) at 2 μg/mL (100 μL/well) on a Nickel Coated plate can bind CLDN1 Recombinant rabbit mAb PBS (SDT-025) with EC50 of 12.98-15.16ng/mL. Immobilized CLDN1 Recombinant rabbit mAb PBS (SDT-025) at 2.0μg/mL (100μL/well) can bind Claudin-1 Flag-His tag Protein, Human (Detergent) (Cat. No. UA060017) with EC50 of 5.73-7.98ng/mL.标记
Unconjugated标签
Flag Tag, His Tag性状
Liquid缓冲体系
50mMTris,PH7.5,150mMNaCl,0.05%DDM
储存条件
·6 months from date of receipt, -60 to -80 °C as supplied.
·about 3 days in 2 to 8 °C.
·Please avoid repeated freeze-thaw cycles.文献引用
Zuo D, Zhang J, Liu T, et al. Claudin‐1 Is a Valuable Prognostic Biomarker in Colorectal Cancer: A Meta‐Analysis[J]. Gastroenterology Research and Practice, 2020, 2020(1): 4258035.
Claudins are major components of tight junction complexes that regulate epithelial permeability. Claudin 1 (CLDN1), a member of the Claudin family, is a key membrane protein in tight junctions. CLDN1 is essential for preventing the paracellular diffusion of small molecules through tight junctions in the epidermis, maintaining the skin's normal barrier function. Loss-of-function mutations in CLDN1 result in neonatal ichthyosis-sclerosing cholangitis syndrome. Studies have shown that CLDN1 plays a regulatory role in cancer and may serve as a potential therapeutic target. Additionally, evidence indicates that Claudins are important in tumor immunotherapy and have significant therapeutic potential. The Claudin 1 protein product may enhance the development of drug discovery efforts related to its therapeutic potential.
电泳JSON
1μg (R: reducing condition, N: non-reducing condition).
ELISA
Immobilized Claudin-1 TGP-Flag-His tag Protein, Human (Detergent) (Cat. No. UA060017) at 2 μg/mL (100 μL/well) on a Nickel Coated plate can bind CLDN1 Recombinant rabbit mAb PBS (SDT-025) with EC50 of 12.98-15.16ng/mL.
Immobilized CLDN1 Recombinant rabbit mAb PBS (SDT-025) at 2.0μg/mL (100μL/well) can bind Claudin-1 TGP-Flag-His tag Protein, Human (Detergent) (Cat. No. UA060017) with EC50 of 5.73-7.98ng/mL.
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