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物种
Human分子别名
Claudin-6; Skullin; CLDN6; Claudin6; Skullin 2Accession
P56747浓度
0.11 mg/ml by Nanodrop表达序列
Wild type full length with Flag tag at N-Terminal，and His tag at C-Terminal
表达宿主
HEK293分子量
25.6 kDa
纯度
＞85% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Unconjugated标签蛋白&酶切位点
N/A标签
Flag Tag, His Tag性状
Liquid缓冲体系
50 mM Tris, pH 7.5, 150 mM NaCl, 0.05% DDM
储存条件
·6 months from date of receipt, -60 to -80 °C as supplied.
·about 3 days in 2 to 8 °C.
·Please avoid repeated freeze-thaw cycles.文献引用
1. Du H, Yang X, Fan J and Du X: Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation (Review). Mol Med Rep 24: 677, 2021.
Tight junctions (TJs) are essential components of cell connectivity, maintaining cell polarity, permeability, and adhesion, and participating in the regulation of cell proliferation and differentiation. The claudin (CLDN) family is integral to TJs, with Claudin 6 (CLDN6) being a key member. CLDN6 is a transmembrane protein found in tight junctions, featuring two extracellular loops and intracellular N- and C-terminal tails. CLDN6 modulates ion- and charge-specific permeability in the paracellular pathway of most epithelial tissues.CLDN6 is widely expressed in various tumors, including liver, ovarian, endometrial, and esophageal cancers, as well as atypical teratoid/rhabdoid tumors. Given its expression profile, CLDN6 has potential as a carcinoembryonic antigen and a therapeutic target.
电泳(SDS-PAGE)
0.5μg (R: reducing condition, N: non-reducing condition).
ELISA
Immobilized Human Claudin-6 Antibody at 2.0 μg/mL (100μL/well) can bind Claudin6 membrane Protein with Flag and His tag in detergent, Human (Cat. No. UA060005) with EC50 of 7.7-15.7ng/mL.
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