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产品中心 药物靶点和Fc受体 同型对照

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IgG1 Fc Protein, Mouse

Ig gamma-1 chain C region,IGHG1

价格 ￥650.00 （ 供应商现货 ： 3-5个工作日）
货号 UA050003
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Mouse

    • 分子别名

      Ig gamma-1 chain C region;IGHG1

    • Accession

      AAK53870.1

    • 表达序列

      VPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK

    • 表达宿主

      HEK293

    • 分子量

      28-31 kDa(Reducing)

    • 纯度

      ＞95%, by SDS-PAGE under reducing conditions

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.
    背景介绍

    • Immunoglobulin G (IgG) is a monomer immunoglobulin, mainly involved in secondary antibody reaction, plasma B cell synthesis and secretion, constitute 75% of human serum immunoglobulin. There are four subtypes of human IgG antibodies: IgG1,IgG2,IgG3,IgG4; mice IgG can be divided into five subtypes; IgG1,IgG2A,IgG2B,IgG2C and IgG3; rats have four subtypes: IgG1,IgG2A,IgG2B and IgG2C. The nomenclature of IgG subtypes of different species is independent, so there is no correlation among different genera. The content of IgG1 in serum accounts for about 60%, and the half-life in serum is about 21 days. After pepsin cleavage, IgG1 is divided into two antigenic binding sites F (ab) s and a highly conserved Fc fragment, and Fc has a highly conserved N-glycosylation site. IgG1 is the most potential subtype in tumor immunotherapy. The active form of IgG1 is bivalent monomer, and human IgG1 can also bind to mouse Fc γ receptor, so the obvious effect can be observed in mouse model.

    • 电泳

      • IgG1 Fc, Mouse，1μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.

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