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产品中心 药物靶点和Fc受体 同型对照

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IgG1 Fc Protein, Human

IgG1 Fc,g gamma-1 chain C region,IGHG1

价格 ￥650.00 （ 供应商现货 ： 3-5个工作日）
货号 UA050001
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • 分子别名

      IgG1 Fc;g gamma-1 chain C region,IGHG1

    • Accession

      P01857-1

    • 表达序列

      EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

    • 表达宿主

      HEK293

    • 分子量

      32-34 KDa(Reducing)

    • 纯度

      ＞95%, by SDS-PAGE under reducing conditions

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      Human Fc Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4, 5% trehalose

    • 溶解方法

      Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.
    背景介绍

    • Fc is a crystallizable fragment composed of the carboxyl terminal of two kinds of immunoglobulin heavy chain, which is connected to each other by disulfide bond. The Fc fragment contains the carboxyl terminal part of the heavy chain fixation region, which is responsible for the effect function of immunoglobulin (complement fixation, binding to the cell membrane through Fc receptors, and placental transport). It is reported that IgG1 Fc, as a potential anti-inflammatory drug, plays a new role in the treatment of human autoimmune diseases.

    • 电泳

      • IgG1 Fc, Human ，2μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.

    • ELISA

      • Immobilized Biotinylated FcγRIIa/CD32a(H167) Avi&His Tag, Human (Cat. No. UA010430) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind IgG1 Fc, Human (Cat. No. UA050001) with EC50 of 0.38-0.44 μg/ml.

      • Immobilized Biotinylated FcγRIIA/CD32a(R167) His&Avi Tag, Human(Cat. No. UA010748) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind IgG1 Fc, Human (Cat. No. UA050001) with EC50 of 0.37-0.48 μg/ml.

      • Immobilized Biotinylated Fc γ RIIIa/CD16a(V176) Avi&His Tag Protein, Human (Cat. No. UA010763) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind IgG1 Fc Protein, Human (Cat. No. UA050001) with EC50 of 0.46-1.14μg/ml.

    • SPR

      • Anti-His antibody Immobilized on CM5 Chip captured CD16b(NA1) His Tag, Human (Cat. No. UA020006), can bind IgG1-Fc (UA050001) with an affinity constant of 9.237 μM as determined in SPR assay (Biacore T200).

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