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CXCL4/PF4 Protein, Human

Platelet factor 4,PF-4,C-X-C motif chemokine 4,Iroplact,Oncostatin-A

价格 ￥690.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040566
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Platelet factor 4, PF-4, C-X-C motif chemokine 4, Iroplact, Oncostatin-A

  • Accession

    P02776

  • 表达序列

    Glu 32-Ser101 with His Tag at the C-Terminus

  • 表达宿主

    Yeast

  • 分子量

    12-13 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Determined by its ability to chemoattract THP-1 using a concentration range of 0.01-10.0 ng/ml.

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Sodium Citrate, 150mM NaCl, 5% Trehalose, pH5.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Nat Commun. 2023 Aug 16;14(1):4375.
    Cytokine Growth Factor Rev. 2011 Feb;22(1):1-18.

背景介绍

  • CXCL4, also known as Platelet Factor 4 (PF4), is a member of the C-X-C chemokine family and was the first chemokine to be identified. The human PF4 gene encodes a small protein of approximately 7.8 kDa comprising 70 amino acids in its mature form. CXCL4 is predominantly localized within the alpha granules of platelets, with a remarkably high concentration of approximately 20 μg of PF4 present in every 1×10⁹ platelet cells. In plasma, PF4 is found at a concentration of approximately 2–10 ng/mL.

    CXCL4 exerts pleiotropic biological functions. It is recognized as a potent antiangiogenic chemokine that inhibits endothelial cell proliferation and migration, leading to suppression of angiogenesis. The angiostatic activity of CXCL4 involves multiple mechanisms, including interference with angiogenic growth factors such as bFGF-2 and VEGF165, activation of the CXCR3B receptor (a splice variant of CXCR3), interactions with integrins, and interference with cell cycle progression.

  • 生物活性

    • Determined by its ability to chemoattract THP-1 using a concentration range of 0.01-10.0 ng/ml.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

    • >95% as determined by RP-HPLC.

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