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β-NGF Protein, Human

Beta-nerve growth factor,Beta-NGF

价格 ￥760.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040558
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Beta-nerve growth factor, Beta-NGF

  • Accession

    P01138

  • 表达序列

    Ser122-Ala241

  • 表达宿主

    E.coli

  • 分子量

    12-13 kDa (Non-Reducing)

  • 纯度

    >95% by SDS-PAGE & HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 = 0.36-0.42 ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Cureus. 2025 Jun 11;17(6):e85814.
    Pain. 2019 May 22;160(10):2210–2220.

背景介绍

  • β-NGF is the biologically active form of Nerve Growth Factor (NGF), a founding member of the neurotrophin family essential for neuronal development, survival, and function. Human β-NGF is a homodimeric protein composed of two identical 118-amino acid polypeptide chains. It is processed from a larger precursor (proNGF) through proteolytic cleavage.

    β-NGF represents a fundamental neurotrophic factor with broad applications spanning from basic neuroscience research to clinical therapeutics. While recombinant human β-NGF and gene therapy approaches aim to harness its neuroprotective properties for neurodegenerative diseases, the most significant industrial success has been the development of anti-NGF monoclonal antibodies for chronic pain management. The dual role of NGF—promoting neuronal survival in development while mediating pathological pain in adulthood—highlights the complexity of targeting this pathway therapeutically.

  • 生物活性

    • Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The EC50 for this effect is 0.36-0.42 ng/ml.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

    • >95% as determined by RP-HPLC.

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