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FGF-basic(146aa) Protein, Salmon

bFGF,FGF-2,Heparin-binding growth factor 2,Basic fibroblast growth factor,FGFB,HBGF-2,FGF2,Fibroblast Growth Factor 2 (Basic)

价格 ￥1,200.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040555
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Salmon

  • 分子别名

    bFGF, FGF-2, Heparin-binding growth factor 2, Basic fibroblast growth factor, FGFB, HBGF-2, FGF2, Fibroblast Growth Factor 2 (Basic)

  • Accession

    A0A1S3ST36

  • 表达序列

    Pro10-Arg155

  • 表达宿主

    E.coli

  • 分子量

    14-15 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE & HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 = 0.01-0.017 ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. J Biol Chem. 1996 Jun 21;271(25):15292-7.
    2. Biosci Rep. 2017 Apr 10;37(2): BSR20170173.Print 2017 Apr 28.
    3. Biochem Biophys Res Commun. 1986 Mar 13;135(2):541-8.

背景介绍

  • Basic fibroblast growth factor (bFGF), also known as FGF2, is a member of the fibroblast growth factor (FGF) family. It is a highly specific chemotactic and mitogenic factor for many cell types, appears to be involved in remodeling damaged tissue, such as ulcer healing, vascular repair, traumatic brain injury (TBI). bFGF is a critical component of human embryonic stem cell culture medium. In addition, bFGF protein is a heparin-binding cationic protein involved in a variety of pathological conditions including angiogenesis and solid tumour growth. Thus, bFGF is regarded as a target for cancers chemopreventive and therapeutic strategies.

  • 生物活性

    • Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells, the EC50 for this effect is 0.01-0.017 ng/ml.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • >95% as determined by SEC-HPLC.

  • 反相高效液相色谱(RP-HPLC)

    • >95% as determined by RP-HPLC.

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