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物种
Human分子别名
Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand (HVEM-L; Herpesvirus entry mediator ligand)Accession
O43557表达序列
Asp74-Val240 with His Tag at the N-Terminus
表达宿主
HEK293分子量
20-25, 40-42 kDa (Reducing)
纯度
>95% by SDS-PAGE.内毒素含量
<0.1EU/μg活性
EC50 < 0.39 ng/mL标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
J Clin Invest. 2001 Dec;108(12):1771-80.
TNFSF14, also known as tumor necrosis factor ligand superfamily member 14 or LIGHT (homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), is a cytokine belonging to the tumor necrosis factor (TNF) superfamily. TNFSF14 is a type II transmembrane protein that can be cleaved to produce a soluble form. It functions as a ligand for two receptors, herpes virus entry mediator (HVEM) and lymphotoxin beta receptor (LTβR), and is involved in regulating immune responses, inflammation, and lymphoid organ development. TNFSF14 has been implicated in various physiological and pathological processes, including the modulation of T cell activation, the regulation of immune cell migration, and the promotion of antitumor immunity.
生物活性
Determined by its cytotoxic effect on HT-29 (human colon adenocarcinoma cells), the EC50 for this effect is less than 0.39ng/mL.
电泳
2μg (R: reducing condition, N: non-reducing condition).
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