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分子别名
Kit ligand, c-Kit ligandAccession
U3IVD8表达序列
Gln26-Ala194 with His Tag at the C-Terminus
表达宿主
HEK293分子量
22-35 kDa (Reducing)
纯度
>95% by SDS-PAGE & HPLC.内毒素含量
<0.1EU/μg活性
Test in progress.标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, 5% trehalose, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
PLoS One. 2012;7(5):e36592.
J Clin Invest. 2008 Jul;118(7):2609-19.
Stem Cell Factor (SCF), also known as KIT ligand (KITL), Steel factor (SF), or mast cell growth factor (MGF), is a critical cytokine encoded by the SCF gene in Anas platyrhynchos (Northern mallard/domestic duck). The duck SCF gene was first molecularly characterized by Li et al., who cloned the full-length cDNA and analyzed its expression patterns in different colored feather bulbs.
SCF is the primary cytokine responsible for self-renewal, proliferation, and differentiation of hematopoietic stem cells (HSCs) in avian species. In mallard models, SCF: Supports sustained proliferation of erythroid progenitors in vitro;
Acts synergistically with IL-3, GM-CSF, and erythropoietin to stimulate hematopoietic colony formation; Maintains HSC quiescence and survival in the bone marrow niche through interaction with c-KIT+ osteoblasts and endothelial cells.
电泳
2μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
>95% as determined by SEC-HPLC.
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