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BMP-7 Protein, Human

Bone morphogenetic protein 7,BMP-7,Osteogenic protein 1 (OP-1),Eptotermin alfa

价格 ￥5,460.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040536
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1 (OP-1), Eptotermin alfa

  • Accession

    P18075

  • 表达序列

    Ser293-His431

  • 表达宿主

    HEK293

  • 分子量

    15-25 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 = 54-69 ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized powder

  • 缓冲体系

    4mM HCl

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Nat Med. 2007 Aug;13(8):952-61
    Nature. 2008 Aug 21;454(7207):1000-4.

背景介绍

  • Bone Morphogenetic Protein-7 (BMP-7), also known as Osteogenic Protein-1 (OP-1), is a member of the transforming growth factor-beta (TGF-β) superfamily and plays a critical role in embryonic development, particularly in skeletal and renal organogenesis. Initially identified in 1990 through independent cloning efforts by Ozkaynak et al. and Celeste et al., BMP-7 was recognized for its potent ability to induce endochondral bone formation. The mature protein functions by binding to type I and type II serine/threonine kinase receptors, activating SMAD-dependent (e.g., SMAD1/5/8) and independent signaling pathways that regulate target genes involved in cell differentiation, apoptosis, and extracellular matrix remodeling. Beyond its osteogenic properties, research over the past two decades has revealed its crucial role as a guardian of epithelial and mesenchymal homeostasis, where it counteracts pro-fibrotic and pro-inflammatory signals, particularly those mediated by TGF-β.

  • 生物活性

    • Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected EC50 for this effect is 54-69 ng/ml.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

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