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IGFBP-2 Protein, Mouse

Insulin-like growth factor-binding protein 2,IBP-2,IGF-binding protein 2,IGFBP-2,mIGFBP-2

价格 ￥780.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040533
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    Insulin-like growth factor-binding protein 2, IBP-2, IGF-binding protein 2, IGFBP-2, mIGFBP-2

  • Accession

    P47877

  • 表达序列

    Gln35-Gln305 with His Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    38-40 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE & HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 = 12-19 ng/ml

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, 1mM EDTA, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Cell Metab. 2010 Jan;11(1):11-22.
    Cytokine Growth Factor Rev. 2015 Jun;26(3):329-46.

背景介绍

  • Insulin-like Growth Factor Binding Protein-2 (IGFBP-2) is a 30–36 kDa secreted protein encoded by the Igfbp2 gene, containing 271 amino acids in the mature form after cleavage of a 34-amino acid signal peptide. Mouse and human IGFBP-2 share approximately 82% homology. IGFBP-2 binds both IGF-I and IGF-II with high affinity, exhibiting 2–10 fold higher affinity for IGF-II than for IGF-I. This binding prolongs IGF half-life and modulates ligand-receptor interactions.

  • 生物活性

    • Measured by its ability to inhibit the biological activity of IGFII on MCF7 human breast adenocarcinoma cells. The EC50 for this effect is 12-19 ng/mL in the presence of 14 ng/mL human IGFII.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

    • >95% as determined by RP-HPLC.

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