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FGF-6 Protein, Human

Fibroblast growth factor 6,FGF-6,Heparin secretory-transforming protein 2 (HST-2,HSTF-2),Heparin-binding growth factor 6 (HBGF-6)

价格 ￥540.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040531
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Fibroblast growth factor 6, FGF-6, Heparin secretory-transforming protein 2 (HST-2; HSTF-2), Heparin-binding growth factor 6 (HBGF-6)

  • Accession

    P10767

  • 表达序列

    Gly41-Ile208

  • 表达宿主

    E.coli

  • 分子量

    14-15 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE, >90% by HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 = 0.037-0.079 ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Genes & Dev. 1997;11(16):2040-2051.
    Nat Commun. 2020;11(1):1421.

背景介绍
  • Fibroblast growth factor 6 (FGF-6), also designated as HST2 or HBGF-6, is a secreted peptide growth factor belonging to the paracrine FGF subfamily. The FGF6 gene, located on human chromosome 12p13, encodes an 18.9 kDa protein that exhibits the highest expression in skeletal muscle and myogenic progenitor cells throughout embryonic development and adulthood. FGF-6 binds preferentially to fibroblast growth factor receptor 4 (FGFR4) with heparan sulfate proteoglycan co-receptor dependency, triggering downstream signaling through the MAPK/ERK1/2 and PI3K/AKT pathways.Functionally, FGF-6 operates as a dose-dependent regulator of myogenesis, promoting satellite cell proliferation at high concentrations and initiating myogenic differentiation via calcineurin-dependent pathways at lower concentrations. Beyond muscle physiology, FGF-6 exhibits pleiotropic functions in bone remodeling, iron homeostasis, thermogenesis, and oncogenesis, harboring both regenerative and tumorigenic activities.

  • 生物活性

    • Determined by a cell proliferation assay using Balb/c 3T3 cells. The EC50 is 0.037-0.079 ng/mL.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

    • >90% as determined by RP-HPLC.

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