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物种
Mouse分子别名
Glia maturation factor beta, GMF-betaAccession
Q9CQI3表达序列
Ser2-His142
表达宿主
E.coli分子量
16 kDa (Reducing)
纯度
>95% by SDS-PAGE and HPLC内毒素含量
<0.1EU/μg活性
Test in progress标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
Trends Cell Biol. 2018 Sep;28(9):749-760.
Nat Rev Neurosci. 2015 Jun;16(6):358-72.
Glia maturation factor-β (GMF-β) is a highly evolutionarily conserved protein belonging to the ADF/cofilin superfamily, first isolated from bovine brain tissue in 1972. Predominantly expressed in the central nervous system (CNS), GMF-β is also detected in various peripheral tissues including colon, thymus, and kidney. As a critical regulator of the Arp2/3 complex-mediated actin cytoskeleton remodeling, GMF-β controls branched actin content, lamellipodial dynamics, and cellular motility. Structurally, GMF-β lacks a classical signal peptide but can be secreted through non-conventional pathways, functioning as both an intracellular signaling molecule and an extracellular modulator of glial cell maturation and differentiation. Whole-body knockout studies in mice demonstrate that GMF-β deficiency is non-lethal, suggesting potential redundancy or compensation mechanisms, yet reveals marked impairments in motor performance, learning capabilities, and inflammatory responses.
电泳
2μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
>95% as determined by RP-HPLC.
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