分享产品介绍 评论(0)
物种
Human分子别名
Glia maturation factor beta, GMF-betaAccession
P60983表达序列
Ser2-His142
表达宿主
E.coli分子量
16 kDa (Reducing)
纯度
>95% by SDS-PAGE and HPLC内毒素含量
<0.1EU/μg活性
Test in progress标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
Trends Cell Biol. 2018 Sep;28(9):749-760.
Nat Rev Neurosci. 2015 Jun;16(6):358-72.
Glia Maturation Factor beta (GMFB) is a 17 kDa intracellular protein primarily expressed in the brain's glial cells, though it is also present in other tissues. As a member of the actin-depolymerizing factor family, it functions as a crucial intracellular regulator of actin cytoskeleton dynamics and cellular signaling pathways (notably enhancing p38 MAPK and inhibiting ERK). Its dysregulation is a key amplifier of inflammatory responses and oxidative stress, linking it to the pathology of numerous diseases.
GMFB is a major driver in diseases like Alzheimer's, Parkinson's, and Multiple Sclerosis, where it promotes glial activation and cytokine release. It is considered a promising therapeutic target; studies show GMFB deficiency protects against neuroinflammation.
电泳
2μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
>95% as determined by RP-HPLC.
评论(0)