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BAFF Protein, Human

Tumor necrosis factor ligand superfamily member 13B,B lymphocyte stimulator (BLyS),B-cell-activating factor,BAFF,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1 (TALL-1)

价格 ￥820.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040517
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator (BLyS), B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1 (TALL-1)

  • Accession

    Q9Y275

  • 表达序列

    Ala134-Leu285

  • 表达宿主

    HEK293

  • 分子量

    16-24 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.01EU/μg

  • 活性

    EC50 = 5.60-10.12 ng/mL

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Nature. 2000 Apr 27;404(6781):995-9.
    Science. 2001 Sep 14;293(5537):2111-4.

背景介绍

  • B-cell activating factor (BAFF), also known as B lymphocyte stimulator (BLyS), is a cytokine that belongs to the tumor necrosis factor (TNF) ligand superfamily and plays a crucial role in regulating B-cell development, survival, and function. In humans, BAFF is primarily produced by myeloid cells, including monocytes, macrophages, and dendritic cells, and acts on B cells through binding to its receptors, BAFF-R, TACI, and BCMA. By engaging these receptors, BAFF promotes the survival, maturation, and antibody production of B cells, as well as the formation of germinal centers and the maintenance of peripheral B-cell populations. Dysregulation of BAFF signaling has been implicated in various autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, highlighting the importance of BAFF in immune homeostasis and autoimmunity.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized BAFF Protein, Human (Cat. No. UA040517) at 2.0μg/mL (100μL/well) can bind BAFFR Fc Chimera Protein, Human (Cat. No. UA011010) with EC50 of 5.60-10.12 ng/mL.

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