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CCL1/I-309 Protein, Human STAR

C-C motif chemokine 1,Small-inducible cytokine A1,T lymphocyte-secreted protein I-309

价格 ￥680.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040504
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    C-C motif chemokine 1, Small-inducible cytokine A1, T lymphocyte-secreted protein I-309

  • Accession

    P22362

  • 表达序列

    Lys24-Lys96

  • 表达宿主

    E.coli

  • 分子量

    10-13 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    J Exp Med. 2013 Jul 29;210(8):1509-28.
    Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2950-4.

背景介绍

  • CCL1 (Chemokine (C-C motif) Ligand 1), also known as I-309 in humans and TCA-3 in mice, is a small glycoprotein belonging to the CC chemokine β-subfamily. Human CCL1 shares ~42% amino acid identity with mouse TCA-3; both contain a unique extra pair of cysteine residues not found in most other chemokines.
    In scientific and industrial fields, CCL1 mainly is focused on CCR8-targeted immunotherapy. CCR8 is an attractive drug target due to its restricted expression pattern (primarily Tregs and Th2 cells) and single human ligand (CCL1), minimizing off-target effects. CCL1 levels are also elevated in bronchoalveolar lavage of asthmatic patients and serum of atopic dermatitis patients .

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

    • >95% as determined by RP-HPLC.

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