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物种
Rat分子别名
Interleukin-17F, IL-17FAccession
Q5BJ95表达序列
Arg29-Ala161
表达宿主
HEK293分子量
18-24 kDa (Reducing)
纯度
>95% by SDS-PAGE and HPLC.内毒素含量
<0.1EU/μg活性
Affinity Constant = 0.17μM标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
Signal Transduct Target Ther. 2023 Oct 11;8(1):402.
J Exp Med. 2008 May 12;205(5):1063–1075.
Interleukin-17F (IL-17F) is a pro-inflammatory cytokine belonging to the IL-17 cytokine family. In rats, IL-17F is predominantly expressed by activated T-helper 17 (Th17) cells, CD8+ T cells, γδ T cells, and innate immune cells such as neutrophils and macrophages. The rat IL-17F protein shares about 55% sequence homology with IL-17A and can form homodimers or heterodimers with IL-17A, both of which exert biological effects by binding to the IL-17 receptor complex (IL-17RA and IL-17RC).
IL-17F is involved in host defense against bacterial and fungal infections and plays a significant role in the pathogenesis of autoimmune and inflammatory diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. In rat models, IL-17F has been shown to induce neutrophil recruitment, promote the release of pro-inflammatory cytokines and chemokines, and contribute to tissue inflammation and bone destruction.
电泳
2μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
>95% as determined by SEC-HPLC.
反相高效液相色谱(RP-HPLC)
>95% as determined by RP-HPLC.
SPR
Protein A Chip captured Human IL-17 RA / CD217 Protein, Fc Tag, can bind IL-17F Protein, Rat (Cat. No. UA040498) with an affinity constant of 0.17μM as determined in SPR assay.
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