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IL-17A Protein, Human STAR

Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8)

价格 ￥380.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040483
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8);

  • Accession

    Q16552

  • 表达序列

    Gly24-Ala155

  • 表达宿主

    HEK293

  • 分子量

    16-20 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 = 1.99-2.45ng/mL

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Cytokine. 2021 Mar:139:154344.
    Nat Rev Rheumatol. 2023 Sep;19(9):535-536.

背景介绍

  • The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 132 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Human Interleukin-17A (IL-17A) is encoded by the IL17A gene located on the chromosome 6 and belongs to the IL-17 family that contains IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The six known members of this family are secreted as homodimers. Human IL-17 exhibits 63% amino acid identity with mouse IL-17，IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant Human IL-17A is a 31.0kDa, disulfide-linked homodimer of two 132 amino acid polypeptide chains.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • >95% as determined by SEC-HPLC.

  • 反相高效液相色谱(RP-HPLC)

    • >95% as determined by RP-HPLC.

  • ELISA

    • Immobilized IL-17A Protein, Human (Cat. No. UA040483) at 5.0μg/mL (100μL/well) can bind Human IL-17 RA / CD217 Protein, Fc Tag with EC50 of 1.99-2.45ng/mL.

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