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IL-33 Full Length Protein, Human

Interleukin-33,IL-33,Interleukin-1 family member 11 (IL-1F11),Nuclear factor from high endothelial venules (NF-HEV)

价格 ￥2,280.00 （ 1-2周）
货号 UA040477
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Interleukin-33; IL-33; Interleukin-1 family member 11 (IL-1F11); Nuclear factor from high endothelial venules (NF-HEV);

  • Accession

    O95760

  • 表达序列

    Met1-Thr270, with N-terminal His Tag

  • 表达宿主

    E.coli

  • 分子量

    33 kDa (Reducing)

  • 纯度

    >90% by SDS-PAGE.

  • 内毒素含量

    <1EU/μg

  • 活性

    EC50 =0.31μg/ml

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Liquid

  • 缓冲体系

    20mM Tris, 500mM L-Arginine, 1mM DTT, pH8.0

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    J Immunol. 2012 Jul 1;189(1):403-10.

背景介绍

  • IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tissues and lymphoid organs, which plays important roles in type-2 innate immunity and human asthma. Recent studies indicate that IL-33 induces production of large amounts of IL-5 and IL-13 by group 2 innate lymphoid cells (ILC2s), for initiation of allergic inflammation shortly after exposure to allergens or infection with parasites or viruses. IL-33 appears to function as an alarmin (alarm signal) rapidly released from producing cells upon cellular damage or cellular stress.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized IL-33 Full Length Protein, Human (Cat. No. UA040477) at 2.0μg/mL (100μL/well)* can bind IL1RL1/ST2 Fc Chimera Protein, Human (Cat. No. UA010464) with EC50 of 0.31μg/ml.
      * PBS is recommended to be used for dilution and coating.

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