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物种
Mouse分子别名
IL-17F,Interleukin-17F,Cytokine ML-1,Accession
Q7TNI7表达序列
Arg29-Ala161表达宿主
HEK293分子量
17-24 kDa (Reducing)纯度
>95% by SDS-PAGE and HPLC.内毒素含量
<0.1EU/μg活性
KD = 4.3μM标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
Immunity. 2019 Apr 16;50(4):892-906.
Cytokine. 2009 Apr;46(1):7-11.
Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).
电泳
2μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
>95% as determined by SEC-HPLC.
反相高效液相色谱(RP-HPLC)
>95% as determined by RP-HPLC.
SPR
Anti-His antibody Immobilized on CM5 Chip captured IL-17 RA Protein, Human (Cat. No. UA040024), can bind IL-17F Protein, Mouse (Cat. No. UA040476) with an affinity constant of 4.331μM as determined in SPR assay.
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