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物种
Mouse分子别名
Interleukin-12 subunit beta,IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40),IL-12 subunit p40Accession
P43432表达序列
Met23-Ser335
表达宿主
HEK293分子量
43-45 kDa (Reducing)
纯度
>95% by SDS-PAGE.内毒素含量
<0.1EU/μg活性
EC50 = 28-43 ng/ml标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
Annu Rev Immunol. 1998:16:495-521.
Nature. 2003 Feb 13;421(6924):744-8.
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of two disulfide-linked subunits, p35 and p40. It plays a crucial role in regulating immune responses, particularly in promoting the differentiation of T helper 1 (Th1) cells and enhancing the cytotoxic activity of natural killer (NK) cells. The p40 subunit is shared between IL-12 and IL-23, another important cytokine involved in immune regulation. In mice, IL-12 p40 is produced by various immune cells, including macrophages, dendritic cells, and B cells. The p40 subunit can also exist as a homodimer or monomer, which can act as an antagonist to IL-12.
The p40 subunit is a target for therapeutic interventions in autoimmune and inflammatory diseases. Monoclonal antibodies against IL-12 p40 have been developed to inhibit its activity and reduce inflammation. Also, IL-12 has potent antitumor activity by stimulating the immune system to attack cancer cells. Recombinant IL-12 or IL-12 vectors are being explored as potential cancer treatments.
电泳
2μg (R: reducing condition, N: non-reducing condition).
ELISA
Immobilized IL-12/IL-23 p40 Homodimer Protein, Mouse (Cat. No. UA040458) at 2.0μg/mL (100μL/well) can bind IL-12 R beta 1 Fc Chimera Protein, Human (Cat. No. UA010956) with EC50 of 28.03-43.41ng/mL.
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