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物种
Human分子别名
HC14,Small-inducible cytokine A8Accession
P80075表达序列
Gln24-Pro99
表达宿主
E.coli分子量
Approximately 7.8 kDa, a single non-glycosylated polypeptide chain containing 70 amino acids.
纯度
＞97% by SDS-PAGE or HPLC.活性
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-100 ng/ml.标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
20 mM PB, with 150 mMNaCl, pH 7.4.
溶解方法
Before use this product, please read the direction below carefully.
This vial must be briefly centrifuged prior to opening to bring the contents to the bottom.
Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃.
Further dilutions should be made in appropriate buffered solutions.
储存条件
For long term storage, the product should be stored ≤ -20℃.
Please avoid repeated freeze-thaw cycles after reconstitution.
12 months from date of receipt, -20 to -70℃ as supplied.
1 month, 2 to 8℃ under sterile conditions after reconstitution.
3 months, -20 to -70℃ under sterile conditions after reconstitution.
Human CCL8, also known as monocyte chemotactic protein 2 (MCP-2) , is belonging to the CC chemokine family hat signal through CCR2 and, with the exception of MCP-1, other CCR receptors. It is encoded by the gene CCL8. MCP-2 has two homogeneous MCP-1 (CCL2) and MCP-3 (CCL7) . These three MCPs were found by IL-1- beta triggered human MG-63 osteosarcoma cells. CCL8 shares 62 % amino acid sequence identity with MCP-1, and shares 58 % amino acid sequence identity with MCP-2. CCL8 has chemotactic function for monocytes, eosinophils and neutrophils. In addition, it can also chemoattract activated NK cells but not monocytes or neutrophils. The MCP family cross-reacts across species. Recombinant Human MCP-2 (CCL8) is an 8.9kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
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