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Activin A Protein, Human/Mouse/Rat (High Active） STAR

Inhibin beta A chain,Activin beta-A chain,Erythroid differentiation protein (EDF)

价格 ￥1,000.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040418
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 分子别名

    Inhibin beta A chain,Activin beta-A chain,Erythroid differentiation protein (EDF),

  • Accession

    P08476

  • 表达序列

    Gly311-Ser426, F368A

  • 表达宿主

    E.coli

  • 分子量

    14 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 < 8.0ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    4mM HCl

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in reconstitution buffer (4mM HCl) after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, -20 to -70 °C as supplied.
    ·1 month, 2 to 8 °C under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16239-44.
    Nature. 2000 Mar 23;404(6776):411-4.
    Dev Cell. 2005 Oct;9(4):535-43.

背景介绍

  • Activin A is a dimeric glycoprotein belonging to the transforming growth factor-beta (TGF-β) superfamily of cytokines. It is involved in various biological processes, including embryonic development, reproductive function, and regulation of the immune system. Activin A is produced by a wide range of cell types, including immune cells, endothelial cells, and reproductive tissues. It exerts its effects by binding to the activin type II receptors, leading to the activation of downstream signaling pathways involved in cell proliferation, differentiation, and immune modulation. Activin A has been implicated in the regulation of inflammation, tissue repair, and the pathogenesis of various diseases, including cancer and autoimmune disorders.

  • 生物活性

    • Measured by its ability to inhibition on MPC-11 cell proliferation. The EC50 for this effect is less than 8ng/ml.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

  • ELISA

    • Immobilized Activin A Hyperactive protein, Human/Mouse/Rat (Cat. No. UA040418) at 1.0μg/mL (100μL/well) can bind ACVR2A Fc Chimera Protein, Human (Cat. No. UA010196) with EC50 of 1.17-1.85ng/mL.

    • Immobilized Activin A Hyperactive protein, Human/Mouse/Rat (Cat. No. UA040418) at 1.0μg/mL (100μL/well) can bind ACVR2B Fc Chimera Protein, Human (Cat. No. UA010213) with EC50 of 3.29-7.67ng/mL.

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