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物种
Mouse分子别名
GDNF,Glial-Derived Neurotrophic Facto,ATF-1,ATF2,HFB1-GDNF,HSCR3Accession
P48540表达序列
Met77-Ile211表达宿主
CHO分子量
17~22 kDa (Reducing)
纯度
> 95% by SDS-PAGE & > 95% by HPLC内毒素含量
<0.2EU/μg活性
EC50 < 8.0 μg/ml, measured in a bioassay using C6 cells.标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS
溶解方法
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
储存条件
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. It promotes the survival and differentiation of dopaminergic neurons, and increases their highaffinity dopamine uptake. In a mouse Parkinson’s Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability. GDNF has also been shown to regulate kidney development, spermatogenesis and affect alcohol consumption.
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