热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 蛋白 细胞因子

所有图片（1/2）

IGFBP-5 Protein, Human

Insulin-like growth factor-binding protein 5,IBP-5,IGF-binding protein 5,IGFBP-5

价格 ￥1,000.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040394
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Insulin-like growth factor-binding protein 5, IBP-5, IGF-binding protein 5, IGFBP-5

  • Accession

    P24593

  • 表达序列

    Leu21-Glu272 with His Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    35-80 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 = 54-116 ng/mL.

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Front Endocrinol (Lausanne). 2018 Feb 20;9:53.

背景介绍

  • Insulin-like growth factor-binding protein 5 (IGFBP-5) is a member of the IGFBP family, which consists of six high-affinity binding proteins (IGFBP-1 to IGFBP-6) that regulate the bioavailability and activity of insulin-like growth factors (IGFs), namely IGF-I and IGF-II. IGFBP-5 is a multifunctional protein that not only modulates IGF signaling but also exhibits IGF-independent functions. It is widely expressed in various tissues, including bone, breast, prostate, and the cardiovascular system, and plays a critical role in cellular growth, differentiation, apoptosis, and tissue development.
    IGFBP-5 is involved in various diseases, including cancer, diabetes, and cardiovascular disorders. In cancer, IGFBP-5 exhibits dual roles, acting as either a tumor suppressor or promoter depending on the cellular context. For example, it is overexpressed in aggressive glioblastoma and osteosarcoma, where it promotes tumor invasion and metastasis. Conversely, in breast cancer, IGFBP-5 can inhibit tumor growth by inducing apoptosis.

  • 生物活性

    • Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF‑7 human breast cancer cells. The EC50 for this effect is 54-116 ng/mL in the presence of 14 ng/mL rhIGF-II.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

评论(0)